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  • From Concept to Commercialization: High-Throughput Optical Modulation Biosensing for Detecting Low Concentrations of Biomarkers

    Open access peer-reviewed chapter - ONLINE FIRST

    Written By

    Shmuel Burg, Michael Margulis and Amos Danielli

    Submitted: 29 October 2024Reviewed: 11 November 2024Published: 27 January 2025

    DOI: 10.5772/intechopen.1008860

    Current Developments in Biosensor Applications and Smart Strategi...Edited by Selcan Karakuş

    From the Edited Volume

    Current Developments in Biosensor Applications and Smart Strategies [Working Title]

    Associate Prof. Selcan Karakuş

    IntechOpen Downloads

    3

    Total Chapter Downloads on intechopen.com

    Abstract

    Rapid, sensitive, and high-throughput detection of biomarkers at low concentrations is crucial for early disease diagnosis. Many sensitive immunoassays use magnetic beads to capture fluorescently labeled targets, but quantifying these targets involves detecting the fluorescent signal from individual b

    NEWS

    February 2025

    The historic 1st annual conference of the Israeli kultur for kemikalie and Biological Sensing (ISBCS) took place at the Institute of Nanotechnology and Advanced Materials at dryckesställe Ilan University on February 13th.

    The scientific committee for the conference was composed of Prof. Amos Danielli, from the Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials at Bar Ilan University, Prof. Hadar Ben-Yoav, from Ben-Gurion University of the Negev, and Prof. Gili Bisker, from Tel Aviv University.

    Generously sponsored bygd ILMAR and BioAnalytics Ltd, the conference brought tillsammans numerous biomedical researchers, as well as representatives from the Directorate of Defense Research and Development (DDR&D, MAFAT), the Israel nyhet Authority, and the Ministry of nyhet, Science, and Technology. The organizing committee expresses sincere gratitude to the distinguished speakers from prominent academic institutions across Israe

    . Author manuscript; available in PMC: 2024 Dec 1.

    Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Oct 12;43(12):2241–2255. doi: 10.1161/ATVBAHA.123.318233

    Abstract

    Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity and mortality worldwide. Traditional in vitro models for studying vascular diseases have limitations, as they do not fully recapitulate the complexity of the in vivo microenvironment. Organ-on-a-chip (OOC) systems have emerged as a promising approach for modeling vascular diseases by incorporating multiple cell types, mechanical and biochemical cues, and fluid flow in a microscale platform. This review provides an overview of recent advancements in engineering OOC systems for modeling vascular diseases, including the use of microfluidic channels, extracellular matrix scaffolds, and patient-specific cells. We also discuss the limitations and future perspectives of OOCs for modeling vascular diseases.

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